In Greece, the new Law 4653/2020 previews the development of Centers of Excellence in higher education to support good practices in quality and innovation. Similar approaches have been undertaken throughout Europe: a few examples are the Basque VET Plan (in Northern Spain), which makes it a core priority to face the challenges of industries and transforms VET centres into High-Performance Centres, or Sardinia’s in its “Intelligent Specialization Strategy”, which distinguishes 3 “fundamental” production themes Agro-industry, Tourism-cultural and environmental heritage and ICT, plus Networks for the Efficient Management of Energy in Italy. Criteria for the Centers of excellence are the quality and effectiveness of teaching and research work, the relevance of curricula, the connection between education and research, international cooperation and the high quality of support services.